Heterosynaptic Modulation of Long-Term Potentiation at Mossy Fiber Synapses in Hippocampus
Final technical rept. 1 Apr 1988-31 Mar 1991,
BAYLOR COLL OF MEDICINE HOUSTON TX
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The overall goal of this research project was to investigate the cellular and membrane mechanism associated with heterosynaptic modulation of long-term synaptic potentiation LTP at mossy fiber synapses in the hippocampus. Previous work in this laboratory had shown that norepinephrine NE , through Beta-adrenoceptors, enhances the magnitude, duration, and probability of induction of mossy fiber LTP. We also had preliminary evidence that acetylcholine ACh, through muscarinic reporters, depresses the magnitude and probability of induction of mossy fiber LTP. We hypothesized that the heterosynaptic modulation of mossy fiber LTP was through modulation of voltage- gated calcium channels. That is, the modulation of LTP by NE results from an enhancement of voltage-gated calcium channels, while suppression of LTP by ACh was through a decrease in activity of voltage-gated calcium channels.
- Anatomy and Physiology
- Medicine and Medical Research