Phosphoprotein Regulation of Synaptic Reactivity
Annual technical rept. 3 Jan 1990-28 Feb 1991,
NORTHWESTERN UNIV EVANSTON IL COLL OF ARTS AND SCIENCES
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The regulation of synaptic reactivity by protein kinase C and its substrates has been studied using the long-term potentiation paradigm LTP. We have studied the effects of protein kinase C activators and inhibitors on behavior imprinting in the chick and radial arm maze performance. The main conclusion to be drawn is that PKC is necessary but not sufficient for the enhanced durability of memory. In combination with a neural signal, however, PKC demonstrates a profound synergism. Synergism is also observed in the analysis of metal ion regulation of PKC activity. Calcium and zinc interact in their effect on the enzyme in a bidirectional manner. Significant accomplishments made during the period were determining the effect of inhibitors on behavior and the species generality of PKC-F1 module in memory formation.
- Medicine and Medical Research