A Study of the Effect of Hydrocarbon Structure on the Induction of Male Rat Nephropathy and Metabolite Structure
Annual rept. 1 Jun 1990-31 May 1991,
WRIGHT STATE UNIV DAYTON OH DEPT OF CHEMISTRY
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The identification of the urinary metabolites have been identified using gas chromatography GC and gas chromatographymass spectrometry GCMS. Histopathologic examination of the kidneys revealed minimal hyaline droplet formation alpha 2u-globulin nephropathy in the proximal tubule area from 2- methylheptane 2-MH. While 2,5-dimethylhexane 2,5-DMH revealed moderate hyaline droplet formation in the renal proximal tubule. Work is currently progressing on the metabolism of 3-methylheptane. There are 16 separate metabolites which have been found, but only 3 have been identified. This molecules metabolism is very complex. Pathological results indicate that it is more nephrotoxic than 2-methylheptane or n-octane, two structural isomers.
- Medicine and Medical Research