Investigation of the Hepatotoxic and Immunotoxic Effects of the Peroxisome Proliferator Perfluorodecanoic Acid
Annual technical rept. 30 Sep 90-30 Apr 91,
OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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Our research efforts of the past six months have involved evaluation of the immunotoxic and toxic effects of perfluorodecanoic acid PFDA. Eight day exposure to PFDA caused thymic atrophy with marked thymocyte depletion as well as decreased spleen cellularity at 50 mgkg. Con A-induced T cell mitogenic responses were decreased at 20 mgkg PFDA, but no effect on B cell proliferation was observed. Antigen-induced proliferation was decreased in both 20 and 50 mg kg PFDA-exposed animals, although delayed-type hypersensitivity reactions did not vary significantly from control animals. Interestingly, IL-2 activity of cell culture supernates was increased with PFDA exposure, although NK cell activity was similar to control and lymphocyte subsets Th and Tsc cells were not affected.
- Medicine and Medical Research