Interactions of Neuromodulators with Cells of the Immune System
Final rept. 1 Nov 1986-31 Oct 1989
ILLINOIS UNIV AT CHICAGO CIRCLE PERIODONTAL RESEARCH CENTER
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The long term goal of this project has been to define and explain mechanistically, interactions of the immune system with molecules related to biological stress. During the tenure of this proposal, we demonstrated that norepinephrine NE can inhibit both T and B cell activation by mitogens, antigen, and interleukin 2. The use of a clonally derived T cell lymphoma, the S49 cell, and S49 cell mutants unable to synthesize cyclic AMP AdCy or utilize the cyclic AMP-dependent protein kinase PKA revealed that NE effects required the presence of a functioning cyclic AMPprotein kinase A system. Examination of the NE-mediated down regulation of the Thy-1 gene revealed that NE modulation occurs at mRNA transcription and requires the presence of a functional cyclic AMP protein kinase.
- Medicine and Medical Research