The Involvement of the Immune System in Neuronal Plasticity
Final technical rept.
CALIFORNIA UNIV SAN DIEGO LA JOLLA OFFICE OF CONTRACT AND GRANT ADMINISTRATION
Pagination or Media Count:
Damage to the entorhinal afferents to the hippocampal dentate gyrus i.e. perforant path leads to sprouting of the remaining intact septal cholinergic afferents within the denervated outer molecular layer. To investigate the cellular and molecular events which contribute to this sprouting response we describe the temporal sequence of cellular changes in the denervated zone prior to the observed neural reorganization. Rats were given perforant path PP transections and sacrificed at various time points following the lesion, on Days D 1,2,3,4,5,6, and 30. Coronal sections at the level of the dorsal hippocampus were immunostained to localize microglia OX-42, interleukin IL-1 and astrocytes GFAP. We observed a rapid increase in the number of microglia in the denervated molecular layer within the first day following PP transection.
- Medicine and Medical Research