Accession Number:

ADA237516

Title:

Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Volume 1

Descriptive Note:

Final rept. 1985-1987; May 1987-Feb 1991

Corporate Author:

SCIENCE APPLICATIONS INTERNATIONAL CORPMCLEAN VA

Report Date:

1991-03-01

Pagination or Media Count:

207.0

Abstract:

This report presents the results of the serum dioxin analysis of the Air Force Health Study 1987 examination cycle. Its purpose is to determine whether long-term health effects are associated with serum dioxin levels for the participants in the study. For each health effect variable, analyses were performed to evaluate the relationships with initial serum dioxin extrapolated from a first-order pharmacokinetics model current serum dioxin and time since tour and categorized current dioxin levels providing contrasts of Ranch Hands with specified current dioxin levels versus Comparisons with background levels. Significant associations between serum dioxin and several lipid-related health indices were found in these analyses. Specifically, significant associations with dioxin were found for diabetes, percent body fat, cholesterol. High Density Lipoproteins HDL, and cholesterol-HDL ratio. Other variables, such as the spirometric indices in the pulmonary assessment and benign systemic neoplasms over 70 were lipomas in the malignancy assessment, showed significant associations that may be related to the body fat results. Partial contents Dioxin assay Relationship between the exposure index and dioxin body burdens in Ranch Hands Statistical methods Covariate associations and General health assessment.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE