Mouse Hepatitis Virus Infection Suppresses Modulation of Mouse Spleen T- Cell Activation
ILLINOIS UNIV CHAMPAIGN
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Natural infection by mouse hepatitis virus MHV can affect interpretation of immunological studies in mice. MHV, a collective term describing a group of corona viruses, is found in natural infections in over 70 of laboratory mouse populations in the United States and Canada. Natural outbreaks of mouse hepatitis virus MHV in our animal colony afforded us the opportunity to study MHV-induced immunosuppression as well as the effects of MHV infection on neurotransmitter-immunomodulation. Concanavalin A-stimulated DNA synthesis by spleen T-lymphocytes from MHV-infected mice was 20-50 that of noninfected mice.
- Medicine and Medical Research