New Synthetic Receptor Derived from Bridged Anthracenes
Final rept. 1 May 88-31 Dec 90,
CALIFORNIA INST OF TECH PASADENA DIV OF CHEMISTRY AND CHEMICAL ENGINEERING
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The major goal of the present contract was to develop new insights into the forces responsible for the association of organic molecules so often seen in biological systems e.g., enzyme-substrate, antibody-antigen, neuroreceptor-neurotransmitter interactions. To this end, a series of water- soluble organic molecules with well-defined hydrophobic binding sites was prepared, and the being characteristics of several structures were evaluated. The most significant discovery of the investigations was the demonstration of the importance of the cation-pi or, alternatively, ion-dipole interaction in producing tight, oriented binding of a wide variety of onium type guests. High field NMR was the primary tool used to establish the cation-pi interaction as a potent force for binding in both aqueous and organic media.
- Organic Chemistry