Cellular and Tissue Injury during Nonfreezing Cold Injury and Frostbite
Triannual rept. no. 1, Feb-May 91,
CRYOLIFE INC MARIETTA GA
Pagination or Media Count:
Our early efforts on this contract have been devoted to developing key assays and establishing initial model systems for testing. Below we outline the preliminary results of studies testing the effects of stresses encountered during nonfreezing cold injury e.g., low temperature, acidosis, anoxia, elevated inorganic phosphate levels, and intracellular ionic imbalance on the model systems. Once we have established the acute effects, we will then begin to investigate the mechanisms of irreversible damage induced by long- term exposure to these conditions. in addition, we will then apply the methodology to other the sensitive cell types that are involved in clod injury.
- Medicine and Medical Research