Accession Number:

ADA237393

Title:

Cellular and Tissue Injury during Nonfreezing Cold Injury and Frostbite

Descriptive Note:

Triannual rept. no. 1, Feb-May 91,

Corporate Author:

CRYOLIFE INC MARIETTA GA

Personal Author(s):

Report Date:

1991-05-31

Pagination or Media Count:

4.0

Abstract:

Our early efforts on this contract have been devoted to developing key assays and establishing initial model systems for testing. Below we outline the preliminary results of studies testing the effects of stresses encountered during nonfreezing cold injury e.g., low temperature, acidosis, anoxia, elevated inorganic phosphate levels, and intracellular ionic imbalance on the model systems. Once we have established the acute effects, we will then begin to investigate the mechanisms of irreversible damage induced by long- term exposure to these conditions. in addition, we will then apply the methodology to other the sensitive cell types that are involved in clod injury.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE