Accession Number:

ADA237368

Title:

Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 4. Methylchloroform

Descriptive Note:

Final rept. May 87-Sep 90.

Corporate Author:

CLEMENT INTERNATIONAL CORP RUSTON LA K S CRUMP DIV

Personal Author(s):

Report Date:

1990-12-01

Pagination or Media Count:

77.0

Abstract:

Physiologically-based pharmacokinetic PBPK models were developed and exercised to describe the behavior of methyl chloroform MC in mice and humans. Methyl Chloroform was compared to trichloroethylene and perchloroethylene work described in volumes 2 and 3. The models were then applied to risk assessment aspects of MC exposure. The pharmacokinetic work presented here extends the physiologically based pharmacokinetic PBPK models of MC that have been proposed to include prediction of TCA plasma concentrations andor TCA urinary excretion.

Descriptors:

• *EXPERIMENTAL DATA
• VALIDATION
• METHYL RADICALS
• HUMANS
• EXCRETION
• MICE
• URINE
• TRICHLOROETHYLENE
• CHLOROFORM
• RISK
• PHARMACOKINETICS

Subject Categories:

• Toxicology
• Pharmacology
• Organic Chemistry
• Computer Programming and Software

Distribution Statement:

APPROVED FOR PUBLIC RELEASE