Accession Number:

ADA237367

Title:

Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 3. Tetrachloroethylene

Descriptive Note:

Final rept. May 87-Sep 90.

Corporate Author:

CLEMENT INTERNATIONAL CORP RUSTON LA K S CRUMP DIV

Personal Author(s):

Report Date:

1990-12-01

Pagination or Media Count:

98.0

Abstract:

Perchloroethylene PCE is a chemical of relevance to the Air Force Installation Restoration Program IRP efforts. Pharmacokinetics of PCE and available PCE PBPK were reviewed and a preliminary risk assessment was prepared. Physiologically based pharmacokinetic PBPK models developed for PCE were used to examine the behavior of PCE in mice and humans. Uncertainty analysis was applied to the PBPK models used in the risk assessment study. Tetrachloroethylene PERC is a commercially important chemical used as solvents. PERC is also a frequent contaminant of drinking water supplies.

Descriptors:

• *UNCERTAINTY
• RISK
• VALIDATION
• HUMANS
• CHLORINE COMPOUNDS
• SOLVENTS
• PHARMACOKINETICS
• MICE
• WATER SUPPLIES
• ETHYLENES
• EXPERIMENTAL DATA
• DRINKING WATER

Subject Categories:

• Toxicology
• Pharmacology
• Organic Chemistry
• Computer Programming and Software

Distribution Statement:

APPROVED FOR PUBLIC RELEASE