Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 2. Trichloroethylene
Final rept. May 87-Sep 90.
CLEMENT INTERNATIONAL CORP RUSTON LA K S CRUMP DIV
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This volume describes the design, development and execution of physiologically based pharmacokinetic modeling as they apply to trichloroethylene TCE exposure in humans. Emphasis is also on TCE metabolites, trichloroacetic acid TCA. PBPK human models for TCE risk assessment provided a basis for interspecies comparisons and a basis for cancer risk assessment. Trichloroethylene TCE are of interest because of recent studies showing TCE to be carcinogenic to rodents. Mice exposed to TCE by inhalation and via gavage developed hepatocellular tumors while rats exposed orally developed kidney tumors. A major metabolite of TCE, trichloroacetic acid TCA, and a minor metabolite, dichloroacetic acid DCA, have also been shown to cause hepatocellular tumors in mice when administered in drinking water.
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