Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 1. Executive Summary/Introduction
Final rept. May 87-Sep 90.
CLEMENT INTERNATIONAL CORP RUSTON LA K S CRUMP DIV
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Physiologically-based pharmacokinetic PBPK modeling as a risk assessment tool is sensitive to uncertainties and variation in model parameters. This volume summarizes the approaches taken to 1 describe the construction of PBPK models for trichloroethylene, tetrachloroethylene, methylchloroform and vinyl chloride and 2 study the uncertainty associated with PBPK models and model parameters. Also discussed in this volume is the methodology involved with risk assessment software development and execution of a sensitivityuncertainty analysis.
- Computer Programming and Software