Accession Number:

ADA237365

Title:

Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 1. Executive Summary/Introduction

Descriptive Note:

Final rept. May 87-Sep 90.

Corporate Author:

CLEMENT INTERNATIONAL CORP RUSTON LA K S CRUMP DIV

Personal Author(s):

Report Date:

1990-12-01

Pagination or Media Count:

53.0

Abstract:

Physiologically-based pharmacokinetic PBPK modeling as a risk assessment tool is sensitive to uncertainties and variation in model parameters. This volume summarizes the approaches taken to 1 describe the construction of PBPK models for trichloroethylene, tetrachloroethylene, methylchloroform and vinyl chloride and 2 study the uncertainty associated with PBPK models and model parameters. Also discussed in this volume is the methodology involved with risk assessment software development and execution of a sensitivityuncertainty analysis.

Subject Categories:

  • Toxicology
  • Pharmacology
  • Computer Programming and Software

Distribution Statement:

APPROVED FOR PUBLIC RELEASE