Feasibility Study of Pharmacological Treatment to Reduce Morbidity and Mortality After Brain Injury
Annual rept. 14 Apr 88-13 Apr 89,
NEW MEXICO UNIV ALBUQUERQUE
Pagination or Media Count:
The seven experiments reviewed in this report utilize anatomical, metabolic or biochemical measurements to analyze the mechanisms of amphetamine accelerated recovery from the hemiplegia induced by ablation or contusion injury to rat sensorimotor cortex. After a unilateral contusion produced by focal impact trauma, but not following ablation injury of the same cortical area, secondary neuronal death occurs in the dorsolateral striatum, medial geniculate body and hippocampal CA3 pyramidal and hillar regions of the ipsilateral hemisphere. The severity of this remote histopathological reaction is influenced by the anesthesia employed and is not detectably different when the location of the contusion within the sensorimotor area is varied. The severity of the cell death in the hippocampus but not other areas is significantly reduced by the selective alpha1 noradrenergic receptor agonist methoxamine administered 24 hours posttrauma.