Human Immune Response to HTLV-III Virus Infection in Acquired Immunodeficiency Syndrome
Final rept. 29 Sep 86-31 Jul 90,
MASSACHUSETTS UNIV MEDICAL CENTER WORCESTER
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This contract was awarded for a three year period to study aspects of the human cellular and humoral antibody responses to HIV-1 infections. The major research findings during this study were 1 The memory lymphocytes of HIV-1 infected individuals fail to respond to recall viral antigens including HIV-1 antigen early in the course of HIV-1 infections. This finding made aspects of these research investigations extremely difficult especially the study of T cell responses to HIV-1. 2 We generated human CD4 and CD8 CTL clones to novel epitopes on the HIV-1 gag protein. 3 We generated a human CD8 CTL clone to a novel epitope on the envelope glycoprotein gp 160. 4 We established that the sera of HIV-1 infected patients contain antibodies which enhance infection of FcR receptor bearing cells. 5 We demonstrated the antibody dependent enhancement of HIV-1 infection requires two receptors. Fc receptors and CD4.
- Medicine and Medical Research