Preliminary Program Annual Conference on Shock (13th) Held in Tamarron, Durango, Colorado on 8-11 June 1990
WILEY (JOHN) AND SONS INC NEW YORK
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We studied the therapeutic effects of continuously infused N- acetylcysteine, an O2 radical scavenger N, n6, and terbutaline, a beta2 agonist T, n6, versus dextrose controls C, N6 on hemodynamics and regional albumin extravasation in porcine septic shock. After instrumentation, injection of Tc-labeled red blood cells, and baseline measurements, pigs received a 90 min infusion of 11 or - 9 x 10 kg-1 live Escherichia coli bacteria. Thereafter, therapy was started, and 131I human serum albumin was injected. Images were obtained hourly using a gammacamera and a computer until 5 hours after baseline. Regions of interest were drawn in the Tc images, yielding regional ITc radioactivity ratios, with blood samples as reference.
- Medicine and Medical Research