Immunologic Consequences of Chronic Administration of Pyridostigmine
DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)
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The effect of subchronic administration of pyridostigmine on the immune system was evaluated in rats. Three aspects of the immune reactivity and host defence were measured humoral immunity antibody or B-lymphocyte-mediated Jerne plaque assay and antibody accumulation, cell mediated immunity T- lymphocyte mediated blastogenesis and delayed skin reaction and non-specific resistance macrophage or NK cell activity chemiluminescence. Pyridostigmine was administered by Alzet osmotic minipup to produce a 45-48 reduction in serum cholinesterase. There were no significant differences in any of the parameters that were measured among the control groups of rats or those treated with pyridostigmine. The measurement of body weights, organ weights, hemoglobin, RBC and WBC numbers as well as WBC differentials confirmed the apparent lack of effect of pyridostigmine on immune responsiveness.
- Medicine and Medical Research