New Approaches to Hepatitis A Vaccine Development
Annual rept. 1 Mar 90-28 Feb 91,
NORTH CAROLINA UNIV AT CHAPEL HILL
Pagination or Media Count:
Hepatitis A virus HAV has historically been an important cause of morbidity among U.S. soldiers in the field. Work under this contract is directed at the development of a safe, inexpensive and effective hepatitis A vaccine for use in military personnel. Two main research approaches are under investigation. First, we are characterizing neutralization escape mutants of HAV and examining synthetic oligopeptides representing the suspected surface structures of HAV. Octapeptides have been synthesized on polyethelene pins and probed with polyclonal and monoclonal antibodies in an effort to identify antigenic and potentially immunogenic sequences. We have also determined the ability of poliovirus-HAV chimeric viruses to elicit neutralizing antibodies to HAV.
- Medicine and Medical Research