Accession Number:

ADA237161

Title:

New Approaches to Hepatitis A Vaccine Development

Descriptive Note:

Annual rept. 1 Mar 90-28 Feb 91,

Corporate Author:

NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s):

Report Date:

1991-04-22

Pagination or Media Count:

32.0

Abstract:

Hepatitis A virus HAV has historically been an important cause of morbidity among U.S. soldiers in the field. Work under this contract is directed at the development of a safe, inexpensive and effective hepatitis A vaccine for use in military personnel. Two main research approaches are under investigation. First, we are characterizing neutralization escape mutants of HAV and examining synthetic oligopeptides representing the suspected surface structures of HAV. Octapeptides have been synthesized on polyethelene pins and probed with polyclonal and monoclonal antibodies in an effort to identify antigenic and potentially immunogenic sequences. We have also determined the ability of poliovirus-HAV chimeric viruses to elicit neutralizing antibodies to HAV.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE