Accession Number:

ADA237066

Title:

Microvascular Physiologic and Anatomic Responses of the Guinea Pig to Experimental Arenavirus Infection

Descriptive Note:

Final rept. 1 Jul 1987-31 Mar 1991

Corporate Author:

VETERANS ADMINISTRATION MEDICAL CENTER TUCSON AZ

Personal Author(s):

Report Date:

1991-03-31

Pagination or Media Count:

104.0

Abstract:

These studies complete the physiologic inquiry into the course of Pinchinde virus infection in strain 13 guinea pigs. Findings are categorized into four major groups and include 1 Jejunal capillary protein reflection coefficient was reduced from .75 or - .02 SEM to .52 or - .03 2 In contrast to the lymph flux studies showing subtle leak in jejunal capillaries, intravital microscopic and electron microscopic examination of mesenteric and villous capillaries showed no leak of 170 kD dextran as well as intact intercellular junctions 3 The cause of death from this disease depended on animal size or age. Large animals greater than 700g died in 12-14 days with a severe anion gap metabolic acidosis which may have been ketoacidosis from pancreatic failure 4 As a marker of toxic oxygen free radical production, it was noted that ethane production which was first developed as a useable monitor in these studies is elevated nearly to threefold over the course of the viremia.

Subject Categories:

  • Anatomy and Physiology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE