Accession Number:

ADA235908

Title:

T Lymphocytes from Mice Immunized with Irradiated Sporozoites Eliminated Malaria from Hepatocytes

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1990-01-01

Pagination or Media Count:

8.0

Abstract:

When mice are immunized with radiation-attenuated sporozoites they are solidly protected against sporozoite challenge by an immune response that has been shown to require CD8 lymphocytes in several strains of mice. The target of this CD8 T-cell-dependent immunity has not been established. Immune BALBc mice were shown to develop malaria-specific. CD8 T-cell-dependent inflammatory infiltrates in their livers after challenge with Plasmodium berghei sporozoites. Spleen cells from immune BALBc and C57BL6 mice eliminated hepatocytes infected with the liver stage of P. berghei in vitro. The activity against infected hepatocytes is not inhibited by antibodies to interferon-y and is not present in culture supernatants. It is generally restricted, an indication that malaria antigens on the hepatocyte surface are recognized by immune T-effector cells.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE