Accession Number:

ADA235905

Title:

Localization of CS and Non-CS Antigens in the Sporogonic Stages of Plasmodium Yoelii

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1990-01-01

Pagination or Media Count:

8.0

Abstract:

Charoenvit and associates produced monoclonal antibodies MAbs against sporozoites of Plasmodium yoelii. MAbs NYS1, NYS2, and NYS3 recognized the CS antigen, although each reacts with a different epitope. The remaining 2 MAbs, NYS4 and NYS5, recognized antigens which are not CS protein. The antigen recognized by NYS4 is a 140kDa protein relative molecular mass, M 140000 with a common determinant with the CS protein. The antigen recognized by NYS5 could not be found by Western blotting. Immunofluorescent microscopy IFA demonstrated that 3 MAbs NYS1, NYS2, and NYS3 reacted with the sporozoite surface, although there were slight differences in patterns of reactivity.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE