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Localization of CS and Non-CS Antigens in the Sporogonic Stages of Plasmodium Yoelii
NAVAL MEDICAL RESEARCH INST BETHESDA MD
Pagination or Media Count:
Charoenvit and associates produced monoclonal antibodies MAbs against sporozoites of Plasmodium yoelii. MAbs NYS1, NYS2, and NYS3 recognized the CS antigen, although each reacts with a different epitope. The remaining 2 MAbs, NYS4 and NYS5, recognized antigens which are not CS protein. The antigen recognized by NYS4 is a 140kDa protein relative molecular mass, M 140000 with a common determinant with the CS protein. The antigen recognized by NYS5 could not be found by Western blotting. Immunofluorescent microscopy IFA demonstrated that 3 MAbs NYS1, NYS2, and NYS3 reacted with the sporozoite surface, although there were slight differences in patterns of reactivity.
APPROVED FOR PUBLIC RELEASE