Accession Number:

ADA235904

Title:

Evaluation of an in Vitro Assay Aimed at Measuring Protective Antibodies against Sporozoites

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

• Mellouk, S.
• Berbiguier, N.
• Druilhe, P.
• Sedegah, M.
• Galey, B.
• Yuan, L.
• Leef, M.
• Charoenvit, Y.
• Paul, C.
• Hoffman, S.
• Beaudoin, R.

Report Date:

1990-01-01

Pagination or Media Count:

9.0

Abstract:

The feasibility of successfully developing a vaccine against sporozoite challenge has rested largely on successes in protecting mice and some humans with irradiated sporozoites. Several studies have indicated that antibodies 5, CD8 T cells, and cytokines released by immuno-competent cells can interfere with the pre-erythrocytic phase of parasite development. However, information from malaria animal models have demonstrated that antibodies alone, either monoclonal MAb or polyclonal, can be fully or partially effective in preventing infection in sporozoite challenged animals.

Descriptors:

• *SPOROZOITES
• *IN VITRO ANALYSIS
• MODELS
• HUMANS
• ANTIBODIES
• ANIMALS
• IRRADIATION
• MICE
• PARASITES
• MALARIA
• INFECTIOUS DISEASES
• ERYTHROCYTES
• ASSAYING
• VACCINES
• REPRINTS
• MEASUREMENT

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE