Accession Number:

ADA235902

Title:

A CTL Epitope on the Circumsporozoite Protein of P. Yoelii

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1990-01-01

Pagination or Media Count:

6.0

Abstract:

A vaccine model exists for protection against the preerythrocytic stages of malaria. Humans and rodents can be protected against sporozoite infection by immunization with radiation-attenuated sporozoites. There is evidence from different animal models that both antibodies and T cells may be involved in this immune response. However, when BALBc mice are immunized with Plasmodium yoelii sporozoites, it appears that antibody alone plays a minor protective role, while CD8T cells have critically important anti-sporozoite functions. The parasite antigens recognized by these protective CD8 T cells have not been identified.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE