Accession Number:

ADA235899

Title:

AFRRI Reports First Quarter, January-March 1991

Descriptive Note:

Scientific rept

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

Report Date:

1991-01-01

Pagination or Media Count:

140.0

Abstract:

Ionizing radiation reduces the hosts defenses to infection 1 and enhances its susceptibility to systemic infection due to endogenous and exogenous organisms. Klebsiella pneumoniae is one of the most frequent causes of gram-negative bacteremia, and is especially prevalent in immunocompromised patients. Therapy for severe systemic infection due to gram-negative bacteria generally involves the use of aminoglycosides in combination with beta lactam antibiotics. However, several recently developed quinolone compounds have exhibited high in vitro bactericidal activity against most gram negative bacteria. including K. pneumoniae. In this study, we evaluated the efficacy of oral therapy with several quinolones in a model of experimental septicemia due to orally ingested K pneumoniae in irradiated mice.

Descriptors:

• *DEFENSE SYSTEMS
• THERAPY
• IRRADIATION
• MICE
• INFECTIOUS DISEASES
• KLEBSIELLA PNEUMONIAE
• IONIZING RADIATION
• ORAL INTAKE
• ANTIBIOTICS
• GRAM NEGATIVE BACTERIA
• BACTEREMIA
• MODELS
• SEPTICEMIA

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE