Accession Number:

ADA235894

Title:

Genetic Restriction of Protective Immunity to Plasmodium Yoelii Sporozoites.

Descriptive Note:

Journal article,

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1990-01-01

Pagination or Media Count:

6.0

Abstract:

Ten congenic strains of mice were immunized with irradiated sporozoites of Plasmodium yoelii. When challenged with viable sporozoites, only two strains had a high proportion of animals which did not develop blood-stage infections. Genes both within and outside the H-2 region affected the degree of protection. Immunity did not correlate with anti-sporozoite antibody levels. In vivo depletion of CD8T cells did not alter immunity in two of three congenic strains, implying the existence of a novel mechanism of cell-mediated immunity.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE