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Toxic Hazards Research Unit Annual Report (26th) (1989)
Rept. for 1 Oct 1988-30 Sep 1989
NSI TECHNOLOGY SERVICES CORP DAYTON OH
Pagination or Media Count:
Research activities largely focused on the toxicity of chlorotrifluoroethylene oligomers and the acid metabolic products of this hydraulic fluid material. Initial acute studies also were conducted on a silahydrocarbon hydraulic fluid. Physiologically based pharmacokinetic models were developed, refined, or more substantially validated for several chemicals of Air Force and Navy interest. These included hydraulic fluids, organophosphates, and combustion products. Both in vivo and in vitro studies on chloropentafluorobenzene, a chemical defense training material, were conducted or subcontracted, and efforts were begun to develop the equipment needed for additional studies using primates. Neurotoxicity assessments were conducted for jet engine oils and a model was developed to assess the dermal penetration of a neurotoxic compound found in the combustion products of another lubricating oil. In addition, studies were conducted to characterize the distribution of test agents in inhalation exposure chambers, and to describe the effects of animals on such distributions. The review of work described here includes partially completed efforts that will be reported further in subsequent annual reports.
APPROVED FOR PUBLIC RELEASE