Accession Number:

ADA235743

Title:

A Malaria Sporozoite Surface Antigen Distinct from the Circumsporozoite Protein

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

• Hedstrom, R. C.
• Campbell, J. R.
• Leef, M. L.
• Charoenvit, Y.
• Carter, M.

Report Date:

1990-01-01

Pagination or Media Count:

8.0

Abstract:

The sporozoite of Plasmodium is uniformly covered by a proteinaceous membrane coat which is thought to be composed entirely of the circumsporozoite CS protein. Being the first parasite molecule encountered by the host, the CS protein has been intensively studied and evaluated as a vaccine against malaria. Indeed, experimental immunization with radiation-attenuated sporozoites induces solid protective immunity coincident with the stimulation of both cellular and humoral immunological responses to the CS protein.

Descriptors:

• *MALARIA
• PLASMODIUM
• MOLECULES
• CELLS
• PROTEINS
• SOLIDS
• SURFACES
• RESPONSE
• MEMBRANES
• IMMUNOLOGY
• PARASITES
• SPOROZOITES
• IMMUNITY
• ANTIGENS
• IMMUNIZATION
• VACCINES
• REPRINTS
• STIMULATION(GENERAL)

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE