Accession Number:

ADA235631

Title:

Symposium: Cell Communication in Normal and Uncontrolled Growth.

Descriptive Note:

Abstract rept.,

Corporate Author:

MICHIGAN STATE UNIV EAST LANSING CENTER FOR ENVIRONMENTAL TOXICOLOGY

Personal Author(s):

• Trosko, J. E.
• Chang, C. C.
• Madhukar, B. V.

Report Date:

1990-01-01

Pagination or Media Count:

2.0

Abstract:

Carcinogenesis is a multistep process, involving the irreversible conversion of a stem cell to a terminal-differentiation-resistant cell initiation , followed by the clonal expansion of this cell promotion and by the acquisition of other genetic alterations leading to malignancy progression . The initiation and progression steps seem to be facilitated by mutagenesis. Promotion has been associated with agents and conditions that cause mutagenesis. Gap junctional intercellular communication, a fundamental biological process regulating cell growth and differentiation, has been postulated to play a major role in carcinogenesis. The hypothesis is supported by the fact that many cancer cells have some dysfunction in gap junctional intercellular communication, many tumor-promoting chemicals and several oncogenes i.e., ras, src, mos, neu, but not myc reduce gap junctional intercellular communication, and several growth factors i.e., EGF, TGF-Beta, bovine pituitary extract inhibit gap junction.

Descriptors:

• *CELLS(BIOLOGY)
• *ONCOGENESIS
• ACQUISITION
• CELLS
• GROWTH(GENERAL)
• HYPOTHESES
• IRREVERSIBLE PROCESSES
• CANCER
• SYMPOSIA
• CONVERSION
• PITUITARY GLAND

Subject Categories:

• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE