Accession Number:

ADA235578

Title:

Human Erythrocyte as a Model for Investigating Muscarinic Agonists and Antagonists

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF EXPERIMENTAL THERAPEUTICS

Personal Author(s):

• Tang, Lily C.

Report Date:

1991-01-01

Pagination or Media Count:

6.0

Abstract:

Cholinergic muscarine receptors have been identified in the brain Schiller, 1979, neuromuscular junctions Yamamura and Snyder, 1974 pylorus Gaginella et al., 1980, cardiac aorta Peterson and Schimerlik, 1982 and other tissuesorgans by direct binding assays of radiolabeled cholinergic agonists or antagonists. It is well recognized that the cation channel, the anesthetic site, is coupled to cholinergic receptors Aguilar et al., 1980. The cholinergic muscarinic agonists either stimulate cGMP production or inhibit cAMP production Greengard, 1975. Recently numerous reports have alluded to the existence of four subtypes of muscarinic receptor that can be distinguished by their binding affinities and their amino acid sequences.

Descriptors:

• *MUSCARINE
• *ANESTHETICS
• *TISSUES(BIOLOGY)
• BRAIN
• HUMANS
• FACILITIES
• SEQUENCES
• RECEPTION
• ERYTHROCYTES
• CHANNELS
• ASSAYING
• HEART
• SENSE ORGANS
• AMINO ACIDS
• CHOLINERGIC NERVES
• AORTA
• ORGANS(ANATOMY)
• PRODUCTION
• CATIONS
• COUPLING(INTERACTION)
• REPRINTS

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE