Accession Number:

ADA235505

Title:

Genetic Toxicity Assessment of Triazine T17-2

Descriptive Note:

Final rept. 16 Nov 1989-20 Jun 1990

Corporate Author:

NSI TECHNOLOGY SERVICES CORP DAYTON OH

Report Date:

1990-11-01

Pagination or Media Count:

49.0

Abstract:

Triazine T17-2, a missile gyroscope dampening fluid, was elevated using in vitro bioassays to assess its potential genotoxic activity. The assays conducted were the Ames Salmonellamicrosomal mutagenicity assay and the Chinese hamster ovary CHO gene mutation assay. Triazine did not demonstrate genotoxic potential in either assay therefore the results would predict little or no genetic risk from Triazine T17-2. Triazine T17-2 was tested for potential genotoxic activity in both bacterial and mammalian cell in vitro mutation assay systems. The Ames Salmonella reverse mutation assay was performed with the preincubation method in order to maximize the interaction between the bacteria and Triazine T17-2. Strains TA98, TA100, TA1535, TA1537, and TA1538 were used in the presence and absence of a rat liver S9 metabolic activation system. In mammalian cell culture, Triazine T17-2 was tested for mutagenic activity at the HGPRT locus in CHO cells. After 4 h exposures in the presence and absence of the rat liver S9 activation system, little or no toxicity was observed up to the highest applied dose of 1000 microgramsml.

Subject Categories:

  • Toxicology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE