Accession Number:

ADA235425

Title:

Molecular Biological Studies on the Biogenesis of Human Cholinesterases in vivo and as Directed by Cloned Cholinesterase DNA Sequences

Descriptive Note:

Final rept. 25 Sep 1987-24 Sep 1990

Corporate Author:

HEBREW UNIV JERUSALEM (ISRAEL)

Personal Author(s):

• Soreq, Hermona

Report Date:

1990-10-24

Pagination or Media Count:

156.0

Abstract:

Acetylcholinesterase ACHE is an enzyme long noted for its essential role in the termination of neurotransmission at cholinergic synapses and neuromuscular junctions. Because acetylcholinesterase is the target protein for a variety of neurotoxic compounds, including natural poisons, common agricultural insecticides, and chemical warfare agents, research on this enzyme in man has profound implications for human health and well-being. Together with the related but distinct protein butyrylcholinesterase BCHE, it presents an intriguing model for the basic scientific study of tissue-specific and differential regulation of gene expression employing divergent pathways in protein biosynthesis.

Descriptors:

• *CONTROL
• BIOLOGY
• HUMANS
• MOLECULES
• HEALTH
• ENZYMES
• PROTEINS
• TARGETS
• DEOXYRIBONUCLEIC ACIDS
• SEQUENCES
• GENES
• CLONES
• MUSCLES
• JUNCTIONS
• IN VIVO ANALYSIS
• SYNAPSE
• AGRICULTURE
• ACETYLCHOLINESTERASE
• INSECTICIDES
• POISONS
• CHOLINESTERASE
• NERVES
• CHEMICAL WARFARE AGENTS
• BIOSYNTHESIS
• CHOLINERGIC NERVES
• ACETYLCHOLINE

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE