Accession Number:

ADA235296

Title:

Short Communication: Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278,

Descriptive Note:

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

• Holwitt, Eric A.
• Koda, Erik
• Swenberg, C. E.

Report Date:

1990-01-01

Pagination or Media Count:

4.0

Abstract:

Cellular DNA is one of the critical targets for ionizing radiation. To mitigate the effects of ionizing radiation, the U.S. Army Medical Research and Development Command has synthesized several radioprotective drugs, primarily aminothiol compounds. Many mechanisms responsible for their radioprotective action have been proposed, including radical scavenging, hydrogen atom donation to DNA carbon center radicals, enhancement of DNA repair process, and reduction in the target volume. All of these processes require that the radioprotector or its metabolite be located within molecular distances, less than 50A, from DNA.

Descriptors:

• *VOLUME
• MOLECULES
• ATOMS
• CARBON
• TARGETS
• DEOXYRIBONUCLEIC ACIDS
• HYDROGEN
• SHORT RANGE(TIME)
• REPAIR
• COMMUNICATION AND RADIO SYSTEMS
• MEDICAL RESEARCH
• CELLS(BIOLOGY)
• IONIZING RADIATION
• METABOLITES
• CHEMICAL RADICALS
• RADIOPROTECTIVE AGENTS
• ARMY RESEARCH

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE