Lysosomal Changes in Renal Proximal Tubular Epithelial Cells of Male Sprague Dawley Rats Following Decalin Exposure
ILLINOIS UNIV AT URBANA DEPT OF VETERINARY BIOSCIENCES
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Physiologic proteinuria is a characteristic feature of young adult male rats which may be associated with an androgen-dependent inefficiency of renal protein reabsorption and catabolism. The major component of the proteinuria is a low molecular weight glycoprotein called alpha 2U globulin. The principal cytoplasmic organelle involved with alpha 2U globulin metabolism is the lysosome. The physiologic proteinuria and metabolism of alpha 2U globulin have been associated with a potentially unique susceptibility of male rats to specific xenobiotic-induced nephrotoxicity. Exposure of male rats to compounds such as d-limonene, decalin, 2,2,4-trimethylpentane, and JP-5 jet fuel results in pathologic renal alteration.
- Medicine and Medical Research