Pharmacological Sparing of Protein in Burn Injury.
Annual rept. (Final) 15 Mar 1987-14 Mar 1990
TEXAS UNIV MEDICAL BRANCH AT GALVESTON
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The primary goal of the research studies sponsored by this project was to assess the effect of sepsis andor severe burn injury on the normal anabolic effect of insulin on protein metabolism. All studies were performed in human patients and normal volunteers using stable isotopic tracers and mass spectrometry analysis to quantify various metabolic factors. The first protocol involved the assessment of the effect of seven days bedrest in normal volunteers on glucose and protein responsiveness to insulin. The results following bedrest served as control values for subsequent studies in patients. The most striking aspect of these studies was the modest effect of bedrest, per se, as compared to the responses observed in bedrested patients following severe burn injury or during sepsis. Severe burn injury without systemic sepsis induced only a moderate resistance to the action of insulin on glucose uptake and potassium uptake, when compared to the bedrested controls. Sepsis halved the normal stimulatory effect of insulin on glucose uptake. Potassium uptake remained normally responsive to insulin in septic patients. Further studies are required to delineate a specific dose-response curve between insulin concentration, suppression of protein breakdown, and fat balance in the liver in order to formulate optimal treatment protocols incorporating the administration of insulin as an anabolic agent.
- Medicine and Medical Research