Mechanism of Cytotoxicity of the AIDS Virus, HTLV-III/LAV
Final rept. 31 Mar 1987-30 Jun 1990
WASHINGTON UNIV ST LOUIS MO
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Understanding the mechanism of human immunodeficiency virus HIV type 1 replication and cytopathicity is critical to determining the pathogenesis and treatment of the acquired immunodeficiency syndrome AIDS and associated diseases. Studies of related viruses, simian immunodeficiency virus SIV and HIV-2, complement these studies and allow additional animal model systems for testing hypotheses. We have studied three aspect of HIV pathogenesis. First, a mutagenic analysis of HIV-1, SIV, and HIV-2 genes including gag, env, vif, vpr, nef, and vpx has been performed to decifer their role in replication and cytopathic activity. Second, immunopathogenetic consequences have been studied with respect to the characterization of a lymphotoxin-like molecule which is secreted by HIV-1 infected cells. Third, the structure and function of HIV-1 env variation has been studied in a clustered outbreak of HIV-1 to elucidate the role of envelope alteration in immune evasion and tissue tropism.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research
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