Accession Number:

ADA234849

Title:

Surgical Treatment of Laser Induced Eye Injuries

Descriptive Note:

Mid-term rept. 17 Apr 1989-16 Oct 1990

Corporate Author:

CALIFORNIA UNIV DAVIS

Report Date:

1990-12-05

Pagination or Media Count:

32.0

Abstract:

Subretinal blood within the macula may play a causative role in visual loss in a number of macular diseases. The clinical and histopathologic effects of experimental subretinal hemorrhage were evaluated in the cat. Subretinal hemorrhages were produced by creating a focal neurosensory retinal detachment with micropipette techniques, then inserting a needle tip transsclerally to allow choroidal blood to fill the bleb. Experimental lesions were examined clinically and with light and electron microscopy over a 14 day postoperative period. Initial observations included clot organization with retraction of fibrin strands tearing photoreceptor outer segments. Later degeneration progressed to involve all retinal layers overlaying the clot. Hemorrhages into tissue plasminogen activator did not form fibrin strands nor cause photoreceptor tearing. These findings highlight the potential for improved retinal survival if organized subretinal clot can be eliminated soon after formation.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Lasers and Masers

Distribution Statement:

APPROVED FOR PUBLIC RELEASE