Interaction of Ionizing Radiation, Genetically Active Chemicals, and Radiofrequency Radiation in Human and Rodent Cells
Final rept. 1 Oct 1987-30 Sep 1989
TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO
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The purpose of this project was to investigate the possible interaction between radiofrequency radiation RFR and agents which are known to damage DNA. Experiments were performed using exposures of CHO cells to 350, 850, 1200, and 2450 MHz RFR at up to 40 Wkg and temperatures ranging from 37 to 40 deg C. No genotoxic effect was observed by sister chromotid exchange induction, chromosome aberration induction, or gene mutation at the thymidine kinase locus. At levels at or below 10 mWcm2 and specific absorption rates SARs at or below 4 Wkg, there was no evidence that DNA repair was induced or repair of preexisting DNA damage was inhibited. Adriamycin but not mitomycin c caused a statistically significant increase in the frequency of aberrant cells at 40 deg C with or without RFR. These observations support thermal mechanisms of RFR interaction.
- Medicine and Medical Research