Methylphenidate and Pemoline: Effects on Sleepiness and Mood during Sleep Deprivation
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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Thirty-six male subjects mean age 20.94 participated in a study of the effects of methylphenidate 10 mg every 6 hours 8 doses or pemoline 37.5 mg every 12 hours 4 doses in maintaining alertness during 64 hours of sleep deprivation. Subjective sleepiness was measured by a Visual Analog Scale VAS, objective sleepiness by the number of lapses intertap interval 3 seconds on a 10 minute tapping task, and mood by the Profile of Mood States POMs. Results indicate that 37.5 mg pemoline administered every 12 hours significantly reduced both subjective and objective sleepiness in sleep deprived subjects. Primarily during the circadian throughs but has little effect on self ratings of mood while 10 mg of methylphenidate administered every 6 hours has no significant effect on these measures.
- Stress Physiology