Accession Number:

ADA234622

Title:

Biological Significance of the Immune Response to HTLV-III/HAV

Descriptive Note:

Final rept. 15 Aug 1987-15 Aug 1990

Corporate Author:

DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s):

Report Date:

1990-12-14

Pagination or Media Count:

8.0

Abstract:

Comprehensive studies have been conducted to determine seroreactivity of HIV infected individuals to well defined epitopes on the virus envelope. These have included regions antibodies. The principal neutralizing domain PND of HIV lies within the third hypervariable domain and is represented by a disulfide linked loop residues 303-337. This region contains both variable and conserved epitopes. The ADCC targets are present in both gp120 and gp41 and are represented by conserved domains.

Subject Categories:

  • Biology
  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE