Genetic Toxicity Assessment of 1,3-Dichlorotetrafluorobenzene
Final rept. 24 Jan-16 Sep 1989
HARRY G ARMSTRONG AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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1,3-Dichlorotetrafluorobenzene DCFB, a fully substituted halogenated benzene, was evaluated using in vitro bioassays to assess its potential genotoxic activity. The assays conducted were the Ames salmonella microsomal mutagenicity assay, the Chinese hamster ovary CHO gene mutation assay, the CHOsister chromatid exchange SCE and chromosome aberration assay, the BALBc-3T3 cell transformation assay and an in vivoin vitro unscheduled DNA synthesis assay. DCFB did not demonstrate genotoxic potential in any of the assays. Thus the results of the test battery would predict no genetic risk from exposure to DCFB.