Accession Number:

ADA234221

Title:

Interaction of Electromagnetic Fields with Biosynthetic Processes in Connective Tissue Cells

Descriptive Note:

Final rept. 31 Mar 1989-30 Apr 1990

Corporate Author:

MASSACHUSETTS INST OF TECH CAMBRIDGE DEPT OF ELECTRICAL ENGINEERING AND COMPUTER SCIENCE

Report Date:

1989-12-01

Pagination or Media Count:

57.0

Abstract:

The specific objectives of this research period were 1 determine whether chondrocytes can be maintained in long-term 2-3 months culture in agarose gel in order to test the effects of chronic as well as acute response to exposure to electromagnetic fields 2 measure chondrocyte proliferation, biosynthetic rates for proteoglycans and proteins, total accumulation of proteoglycans, and physical properties of agarosechondrocyte gel cultures 3 construct specialized chambers for application of electric fields to agarose chondrocyte disks in a standard incubator environment and 4 begin experiments to measure the effects of applied current densities over a wide range of amplitudes and frequencies on biosynthesis of proteoglycans and proteins.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE