Pharmacokinetics and Pharmacodynamics of Oximes in Unanesthetized Pigs
Technical rept. Jan-May 1989
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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The pharmacokinetics and cardiovascular pharmacodynamics of three oximes were studied in unanesthetized pigs. Cardiopulmonary parameters were monitored and plasma concentrations of oximes were determined from arterial blood samples taken at intervals over a period of 5 hr postinjection. Plasma concentrations for all oximes were fitted to standard pharmacokinetic models using the computer program PCNONLIN. Average pharmacokinetic parameters were determined for each oxime. Only mild to moderate physiological side effects were detected following intramuscular administration. 2-PAM C1 and ICD 467 were both more rapidly absorbed, with slightly faster distribution and elimination rates for ICD 467. Although MMB-4 had a slight lag time to attain detectable levels in the blood, retention time was longer than for 2-PAM C1 and ICD 467.
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