The Molecular Anatomy of PFDA Hepatotoxicity as Studied by Two- Dimensional Electrophoresis.
Annual rept. 15 Dec 1989-14 Dec 1990
INDIANA UNIV-PURDUE UNIV AT COLUMBUS DEPT OF BIOLOGY
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Perfluoro-n-decanoic acid PFDA effects on protein expression in the rat liver were studied in rodents following in vivo exposure to PFDA levels above, below and at the LD-50. Two-dimensional whole-liver homogenate protein patterns were generated and compared to previous results. As before, numerous proteins were altered some suppressed, some induced, but most were unaffected. In an effort to identify the altered proteins, further analysis off basic proteins by first-dimension NEPHGE revealed the induction of cytochrome P452 lauric acid -oxidase and enoyl-CoA hydratase.
- Medicine and Medical Research