Drug Evaluation in the Plasmodium falciparum - Aotus Model
Annual rept. 15 May-12 Dec 1990; Final rept. 15 May 87-12 Dec 1990,
GORGAS MEMORIAL INST OF TROPICAL AND PREVENTIVE MEDICINE INC BETHESDA MD
Pagination or Media Count:
The objective of these studies was to evaluate experimental antimalarial drugs in the Panamanian night monkey Aotus 1. lemurinus experimentally infected with Plasmodium falciparum. Four folic acid inhibitors were tested against infections of the pyrimethamine-resistant Vietnam Smith strain. Of the four drugs evaluated, pyrimethamine, proguanil, cycloguanil, and a proguanil analog WR 250417, only the proguanil analog had antimalarial activity. A total 3.0 mgkg dose cured infections in 3 to 7 treatments, a 30.0 mgkg total dose cured 6 infections out of 8 treatments, and a total dose of 150.0 mgkg cured infections in 4 of 4 treatments. Six calcium channel blockers were administered with chloroquine in trials to reverse chloroquine-resistance in vivo of Vietnam SmithRE infections. Only desipramine cleared primary parasitemias but did not cure infections.
- Medicine and Medical Research