Acute Oral Toxicity of 3-Chloro-4,4-dimethyl-2-oxazolidinone (Compound 1) in ICR Mice
Institute rept. Jun-Jul 1985
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The acute oral toxicity of 3-chloro-4, 4-dimethyl-2-oxazolidinone Compound 1 was determined in male and female ICR mice by using the oral gavage single-dose method. The median lethal dose was 309 mgkg for male and 332 mgkg for female mice. The predominate clinical observation was a syndrome of generalized malaise which are characterized by inactivity, hunched posture, and rough coat. This syndrome was observed at all dose levels with frequency and severity increasing with dose. One finding of note at the higher dose levels was the presence of hematuria however, there was no obvious evidence of rental pathology observed at necropsy. Lethality was observed primarily during the first 48 hours after dosing and most of the clinical signs were also observed during this time period. These results place 3-chloro-4, 4-dimethyl-2- oxazolidinone in the very toxic category.