Receptor Subtype Alterations: Bases of Neuronal Plasticity and Learning
Final rept. 1 Oct 1988-30 Sep 1990,
BOSTON UNIV MA
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The following findings were reported 1 Oxotremorine-M binding in rabbit thalamus cingulate cortex increased during discriminative avoidance conditioning DAC. This is the first report of behavioral regulation of muscarinic receptors. 2 Excitatory discriminative neuronal activity was documented throughout DAC and there were relationships between training-induced neuronal activity and changes in binding. 3 Turnover of noradrenaline was significantly elevated during DAC suggesting a role for this transmitter in long-term memory. 4 Anterior cingulate cortex lesions uncover discriminative neuronal activity in the striatum and amplify activity in thalamus. 5 The structure connections and spontaneous activity of the lateral magnocellular nucleus in thalamus were described.