Accession Number:

ADA232655

Title:

Receptor Subtype Alterations: Bases of Neuronal Plasticity and Learning

Descriptive Note:

Final rept. 1 Oct 1988-30 Sep 1990,

Corporate Author:

BOSTON UNIV MA

Personal Author(s):

Report Date:

1990-12-18

Pagination or Media Count:

17.0

Abstract:

The following findings were reported 1 Oxotremorine-M binding in rabbit thalamus cingulate cortex increased during discriminative avoidance conditioning DAC. This is the first report of behavioral regulation of muscarinic receptors. 2 Excitatory discriminative neuronal activity was documented throughout DAC and there were relationships between training-induced neuronal activity and changes in binding. 3 Turnover of noradrenaline was significantly elevated during DAC suggesting a role for this transmitter in long-term memory. 4 Anterior cingulate cortex lesions uncover discriminative neuronal activity in the striatum and amplify activity in thalamus. 5 The structure connections and spontaneous activity of the lateral magnocellular nucleus in thalamus were described.

Subject Categories:

  • Psychology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE