An Experimental Brain Missile Wound: Ascertaining Pathophysiology and Evaluating Treatments to Lower Mortality and Morbidity
Annual rept. 14 Apr 1989-13 Apr 1990,
LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS
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Brain missile wounding BMW is accompanied with a concomitant increase in intracranial pressure ICP. Both, BMW with its accompanying increase in ICP or artificially increased ICP, without wounding, caused significant epinephrine EPI depletions 47-68 in the nucleus tractus solitarius NTS, are A1C1, locus coeruleus, raphe nuclei and posterior hypothalamus. EPI was also significantly decreased in the anterior hypothalamus but only in wounded cats. BMW, but not artificially increased ICP, without wounding, also caused significant decreases of norepinephrine NE, dopamine and homovanillic acid the NTS and area A1C1. We conclude that most of the brain stem and hypothalamic biogenic amine changes were probably caused by the cardiovascular effects associated with the stress of increased ICP alone. The results suggest selective monoamine decreases associated with increased ICP the EPI system overall and the 5-HT system in the raphe nuclei.
- Medicine and Medical Research