Accession Number:

ADA231832

Title:

ESR Study of Electron Transfer Reactions between gamma-Irradiated Pyrimidines, Adriamycin and Oxygen

Descriptive Note:

Scientific rept.

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Report Date:

1990-01-01

Pagination or Media Count:

9.0

Abstract:

The direct effect of ionizing radiation on DNA generates mainly guanine and thymine radicals. These radicals have been observed in solid DNA samples using electron spin resonance ESR spectroscopy. However, the exact fate of the guanine and thymine radicals when DNA is in solution is still unclear. One possibility of interest to this work, is the reaction of these radicals with other molecules in the solution generating products which may be harmful to cells. For this reason and as a model, the reaction between Gamma-irradiated pyrimidine bases with adriamycin was studied.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE