Accession Number:

ADA231751

Title:

Interactions Among Drinking and Ground Water Contaminants on Renal and Hepatic Function

Descriptive Note:

Final technical rept. 1 Aug 1986-30 Jun 1990

Corporate Author:

NEBRASKA UNIV MEDICAL CENTER OMAHA

Personal Author(s):

Report Date:

1991-01-03

Pagination or Media Count:

11.0

Abstract:

This project was designed to elaborate on possible effects on monochloroacetate MCA, maleic acid MA and dichloromaleic acid DCMA on liver and kidney function. These studies have revealed important interactions between these test compounds and various known hepato- and nehphrotoxicants. Some of the interactions were of a potentiative nature and some were antagonistic. In addition, chromate appears to enhance the nephrotoxicity of some of these test compounds, an observation consistent with earlier studies in this report on the interactions of chromate with other substances. All of the studies in this report suggest an important role in the tissue non-protein sulfhydryls.

Subject Categories:

  • Medicine and Medical Research
  • Water Pollution and Control

Distribution Statement:

APPROVED FOR PUBLIC RELEASE